Although parkinsonism is considered a core feature of dementia with Lewy bodies (DLB), it is occasionally mild or even absent. I-FP-CIT SPECT has been accepted as a diagnostic support tool in this context, given that low striatal uptake is associated with neuronal loss. The aim of this retrospective study was to look for correlations between I-FP-CIT uptake in the striatum and clinical extrapyramidal signs (EPSs) in patients with a diagnosis of probable DLB to clarify the extent to which the supporting role of I-FP-CIT is related to motor impairment.
Correlation Between 123I-FP-CIT Brain SPECT and Parkinsonism in Dementia With Lewy Bodies : Caveat for Clinical Use / A. Del Sole, G. Perini, M. Lecchi, C. Mariani, G. Lucignani, F. Clerici. - In: CLINICAL NUCLEAR MEDICINE. - ISSN 0363-9762. - 40:1(2015 Jan), pp. 32-35. [10.1097/RLU.0000000000000602]
Correlation Between 123I-FP-CIT Brain SPECT and Parkinsonism in Dementia With Lewy Bodies : Caveat for Clinical Use
A. Del Sole;M. Lecchi;C. Mariani;G. Lucignani;
2015
Abstract
Although parkinsonism is considered a core feature of dementia with Lewy bodies (DLB), it is occasionally mild or even absent. I-FP-CIT SPECT has been accepted as a diagnostic support tool in this context, given that low striatal uptake is associated with neuronal loss. The aim of this retrospective study was to look for correlations between I-FP-CIT uptake in the striatum and clinical extrapyramidal signs (EPSs) in patients with a diagnosis of probable DLB to clarify the extent to which the supporting role of I-FP-CIT is related to motor impairment.File | Dimensione | Formato | |
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Del Sole et al. - 2015 - Correlation between 123I-FP-CIT brain SPECT and parkinsonism in dementia with Lewy bodies caveat for clinical u.pdf
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