A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13–25), structurally related to model compound 5 (2-[(4-aminophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester), were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist
Design of 1-substituted 2-arylmethyl-4,5-methylene-dioxybenzene derivatives as antiseizure agents / Nicola Micale, Giovambattista De Sarro, Guido Ferreri, Maria Zappalá, Silvana Grasso, Giulia Puia, Carlo De Micheli. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 12:13(2004 Jul 01), pp. 3703-3709.
Design of 1-substituted 2-arylmethyl-4,5-methylene-dioxybenzene derivatives as antiseizure agents
Carlo De Micheli
2004
Abstract
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13–25), structurally related to model compound 5 (2-[(4-aminophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester), were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist
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