The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.

Vitamin K and cardiovascular calcification in CKD : is patient supplementation on the horizon? / M. Gallieni, M. Fusaro. - In: KIDNEY INTERNATIONAL. - ISSN 0085-2538. - 86:2(2014 Aug), pp. 232-234.

Vitamin K and cardiovascular calcification in CKD : is patient supplementation on the horizon?

M. Gallieni
Primo
;
2014

Abstract

The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.
nephrology
Settore MED/14 - Nefrologia
ago-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/240016
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