Background: Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer. Methods: To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job-specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents. Results: In male workers, increased risks were found for linen dust (OR= 3.68, 95% CI 1.00-13.6, adjusted for age, smoking and residence), and unspecified DFs (OR= 1.44, 95% CI 1.07-1.94). Small non-significant excess risks were observed for quartz dust (OR= 1.27; 95% CI 0.83-1.93) and man-made vitreous fibers (MMVFs) (OR= 1.82, 95% CI 0.88-3.75). In female subjects, risks were non-significantly associated with paper dust (OR= 1.77, 95% CI 0.74-4.20), and unspecified DFs (OR= 1.52, 95% CI 0.77-3.03). Conclusions: The study showed increased lung cancer risk for selected categories of DFs.

Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia / A. Baccarelli, O. Khmelnitskii, M. Tretiakova, S. Gorbanev, A. Lomtev, I. Klimkina, V. Tchibissov, O. Averkina, C. Rice, M. Dosemeci. - In: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. - ISSN 0271-3586. - 49:6(2006 Jun), pp. 460-467. [10.1002/ajim.20316]

Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia

A. Baccarelli
Primo
;
2006

Abstract

Background: Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer. Methods: To investigate lung cancer risk in relation to exposure to DFs, we identified 540 pathologically-diagnosed lung cancer cases and 582 controls from the 1993-1998 autopsy records of the 88 hospitals of Leningrad Province, Russia. Lifetime job-specific exposure measurements were available for 15 organic, 15 man-made and 28 natural-inorganic agents. Results: In male workers, increased risks were found for linen dust (OR= 3.68, 95% CI 1.00-13.6, adjusted for age, smoking and residence), and unspecified DFs (OR= 1.44, 95% CI 1.07-1.94). Small non-significant excess risks were observed for quartz dust (OR= 1.27; 95% CI 0.83-1.93) and man-made vitreous fibers (MMVFs) (OR= 1.82, 95% CI 0.88-3.75). In female subjects, risks were non-significantly associated with paper dust (OR= 1.77, 95% CI 0.74-4.20), and unspecified DFs (OR= 1.52, 95% CI 0.77-3.03). Conclusions: The study showed increased lung cancer risk for selected categories of DFs.
Glass wool; Linen dust; Man-made vitreous fibers; Occupation; Paper dust; Particles; Quartz
Settore MED/44 - Medicina del Lavoro
giu-2006
Article (author)
File in questo prodotto:
File Dimensione Formato  
20316_ftp.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 112.65 kB
Formato Adobe PDF
112.65 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/23282
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 16
social impact