A physiological spatial heterogeneity of ventricular repolarization (SHVR) is responsible for the T-wave on the ECG. However, an increased SHVR might favor the development of ventricular arrhythmias. The V-index is a metric introduced with the aim of assessing SHVR from ECG. In this work, the V-index was validated by means of 2D computer simulations, using a modified version of the ten Tusscher-Panfilov (TP06) model that accounts for repolarization variability. Synthetic ECG were simulated at 12 different positions at the external surface with two different strategies. Also, a theoretical extension of the V-index definition was derived, to address situations where fluctuations in repolarization times are correlated across nodes. At tissue level, theoretical values of V-index were in agreement with SHVR with a constant pacing (maximum error: 3.4 ms). However, with a variable RR, a selection of stationary beats was necessary to overcome the stronger temporal correlation across nodes (maximum error: 3.2 ms). On the other hand, values of V-index numerically estimated from the ECG were always in agreement with their theoretical values (average error in the estimates: 15 perpendicular to 9%). The results confirmed that the V-index indeed provides an approximate and reliable measure of SHVR.

Validation of the V-index through finite element 2D simulations / R. Sassi, L.T. Mainardi, P. Laguna, J.F. Rodriguez (Computing in Cardiology Series). - In: Computing in Cardiology Conference[s.l] : IEEE, 2013. - ISBN 9781479908844. - pp. 337-340 (( Intervento presentato al 40. convegno CinC tenutosi a Zaragoza nel 2013.

Validation of the V-index through finite element 2D simulations

R. Sassi
;
2013

Abstract

A physiological spatial heterogeneity of ventricular repolarization (SHVR) is responsible for the T-wave on the ECG. However, an increased SHVR might favor the development of ventricular arrhythmias. The V-index is a metric introduced with the aim of assessing SHVR from ECG. In this work, the V-index was validated by means of 2D computer simulations, using a modified version of the ten Tusscher-Panfilov (TP06) model that accounts for repolarization variability. Synthetic ECG were simulated at 12 different positions at the external surface with two different strategies. Also, a theoretical extension of the V-index definition was derived, to address situations where fluctuations in repolarization times are correlated across nodes. At tissue level, theoretical values of V-index were in agreement with SHVR with a constant pacing (maximum error: 3.4 ms). However, with a variable RR, a selection of stationary beats was necessary to overcome the stronger temporal correlation across nodes (maximum error: 3.2 ms). On the other hand, values of V-index numerically estimated from the ECG were always in agreement with their theoretical values (average error in the estimates: 15 perpendicular to 9%). The results confirmed that the V-index indeed provides an approximate and reliable measure of SHVR.
variability; model
Settore INF/01 - Informatica
Settore ING-INF/06 - Bioingegneria Elettronica e Informatica
2013
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/230966
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