Repetitive elements take up >40% of the human genome and can change distribution through transposition, thus generating subfamilies. Repetitive element DNA methylation has associated with several diseases and environmental exposures, including exposure to airborne pollutants. No systematic analysis has yet been conducted to examine the effects of exposures across different repetitive element subfamilies. The purpose of the study is to evaluate sensitivity of DNA methylation in differentially‒evolved LINE, Alu, and HERV subfamilies to different types of airborne pollutants.
Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants / H. Byun, V. Motta, T. Panni, P.A. Bertazzi, P. Apostoli, L. Hou, A. Baccarelli. - In: PARTICLE AND FIBRE TOXICOLOGY. - ISSN 1743-8977. - 10(2013), pp. 28.1-28.10. [10.1186/1743-8977-10-28]
Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants
V. MottaSecondo
;P.A. Bertazzi;A. BaccarelliUltimo
2013
Abstract
Repetitive elements take up >40% of the human genome and can change distribution through transposition, thus generating subfamilies. Repetitive element DNA methylation has associated with several diseases and environmental exposures, including exposure to airborne pollutants. No systematic analysis has yet been conducted to examine the effects of exposures across different repetitive element subfamilies. The purpose of the study is to evaluate sensitivity of DNA methylation in differentially‒evolved LINE, Alu, and HERV subfamilies to different types of airborne pollutants.
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