In this brief article, the use of X-ray computed microtomography (CMT) for the visualization of the three-dimensional structure of pharmaceutical material is discussed. CMT is a non-destructive technique, which provides cross-sectional images based on local X-ray attenuation. The X-ray attenuation is then related to the material density. The results are discussed specifically with reference to the dissolution profile of a modified release tablet (Adalat OROS) at specific time points. This novel technique is complementary to standard compendial pharmaceutical tests, since it integrates information from several experimental methods to provide a more complete picture of specific drug-delivery systems.
X-Ray Computed Microtomography for the Study of Modified Release Systems / D. Traini, G. Loreti, A.S. Jones, P.M. Young. - In: MICROSCOPY AND ANALYSIS. - ISSN 0958-1952. - 22:(2008 Jan), pp. 13-15.
X-Ray Computed Microtomography for the Study of Modified Release Systems
G. LoretiSecondo
;
2008
Abstract
In this brief article, the use of X-ray computed microtomography (CMT) for the visualization of the three-dimensional structure of pharmaceutical material is discussed. CMT is a non-destructive technique, which provides cross-sectional images based on local X-ray attenuation. The X-ray attenuation is then related to the material density. The results are discussed specifically with reference to the dissolution profile of a modified release tablet (Adalat OROS) at specific time points. This novel technique is complementary to standard compendial pharmaceutical tests, since it integrates information from several experimental methods to provide a more complete picture of specific drug-delivery systems.
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