Ethanol is commonly used as an excipient in the manufacture of medicines, including the ones intended for administration in children. However, ethanol cannot be considered an inert substance; on the contrary, its use in pharmaceutical preparations is associated with safety issues. Newborns, infants and children are not able to metabolize ethanol as efficiently as adults; as a consequence, they may be at higher risk of both acute and chronic alcohol-related toxicities.
Safety issues with ethanol as an excipient in drugs intended for pediatric use / G.V. Zuccotti, V. Fabiano. - In: EXPERT OPINION ON DRUG SAFETY. - ISSN 1474-0338. - 10:4(2011 Jul), pp. 499-502. [10.1517/14740338.2011.565328]
Safety issues with ethanol as an excipient in drugs intended for pediatric use
G.V. ZuccottiPrimo
;V. FabianoUltimo
2011
Abstract
Ethanol is commonly used as an excipient in the manufacture of medicines, including the ones intended for administration in children. However, ethanol cannot be considered an inert substance; on the contrary, its use in pharmaceutical preparations is associated with safety issues. Newborns, infants and children are not able to metabolize ethanol as efficiently as adults; as a consequence, they may be at higher risk of both acute and chronic alcohol-related toxicities.File | Dimensione | Formato | |
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