Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of beta endorphin in cirrhotic rats confirming that central neuropeptides are affected by chronic liver failure.
Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis / F. Salerno, C. Bonato, A.E. Panerai, A. Martini, A. Malesci. - In: LIFE SCIENCES. - ISSN 0024-3205. - 33:4(1983 Jul 25), pp. 377-381. [10.1016/S0024-3205(83)80012-5]
Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis
A.E. Panerai;A. MalesciUltimo
1983
Abstract
Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of beta endorphin in cirrhotic rats confirming that central neuropeptides are affected by chronic liver failure.
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