Stress can induce a naloxone reversible and a naloxone non reversible analgesia according to its parameters. We showed that naloxone non reversible analgesia can be reversed by antagonists of the kappa opiate receptor and that naloxone reversible analgesia can be related to mu receptors and beta-endorphin, while the kappa receptor mediated analgesia can be related to dynorphin. We have also shown that the characteristics of the receptors might change in consequence to stress and that the analgesic responses might be modulated by benzodiazepine agonists and antagonists.
Endogenous opioids and their receptors in stress-induced analgesia / A.E. Panerai, M. Bianchi, A. Brini, P. Sacerdote. - In: POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY. - ISSN 0301-0244. - 39:5(1987), pp. 597-607.
Endogenous opioids and their receptors in stress-induced analgesia
A.E. Panerai;A. Brini;P. Sacerdote
1987
Abstract
Stress can induce a naloxone reversible and a naloxone non reversible analgesia according to its parameters. We showed that naloxone non reversible analgesia can be reversed by antagonists of the kappa opiate receptor and that naloxone reversible analgesia can be related to mu receptors and beta-endorphin, while the kappa receptor mediated analgesia can be related to dynorphin. We have also shown that the characteristics of the receptors might change in consequence to stress and that the analgesic responses might be modulated by benzodiazepine agonists and antagonists.Pubblicazioni consigliate
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