Oxidation of 1-alkyl-1,4-butanediols with Acetobacter aceti MIM 2000/28 gave the corresponding γ-lactones in good yields. The biotransformation occurred with intermediate formation of γ-lactols, which are also substrates for oxidation with Acetobacter aceti MIM 2000/28, as validated by selective biotransformation of 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4-en-21,17-carbolactol to drospirenone.
Biocatalytic oxidation of 1,4-diols and γ-lactols into γ-lactones : application to chemoenzymatic synthesis of drospirenone / D. Romano, M. Contente, T. Granato, W. Remelli, P. Zambelli, F. Molinari. - In: MONATSHEFTE FÜR CHEMIE. - ISSN 0026-9247. - 144:5(2013 May), pp. 735-737.
Biocatalytic oxidation of 1,4-diols and γ-lactols into γ-lactones : application to chemoenzymatic synthesis of drospirenone
D. Romano;M. Contente;T. Granato;W. Remelli;P. ZambelliPenultimo
;F. Molinari
2013
Abstract
Oxidation of 1-alkyl-1,4-butanediols with Acetobacter aceti MIM 2000/28 gave the corresponding γ-lactones in good yields. The biotransformation occurred with intermediate formation of γ-lactols, which are also substrates for oxidation with Acetobacter aceti MIM 2000/28, as validated by selective biotransformation of 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4-en-21,17-carbolactol to drospirenone.
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lactones revised.pdf
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