The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+/X+ showed higher plasma levels of LDL cholesterol than children carrying X-/X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.

Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children / E. Verduci, C. Agostoni, M.L. Biondi, G. Radaelli, M. Giovannini, E. Riva. - In: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. - ISSN 0952-3278. - 71:2(2004), pp. 117-120.

Apolipoprotein B gene polimorphism and plasma lipid levels in phenylketonuric children

E. Verduci;C. Agostoni;G. Radaelli;M. Giovannini;E. Riva
2004

Abstract

The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restricton sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+/X+ showed higher plasma levels of LDL cholesterol than children carrying X-/X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.
Serum-cholesterol; DNA polymorphism; responsiveness; locus; diet
Settore MED/38 - Pediatria Generale e Specialistica
2004
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0952327804000304-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 175.71 kB
Formato Adobe PDF
175.71 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/6280
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact