AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed preferentially by microvessels, favoring angiogenesis and increasing permeability. Recently, we have demonstrated that AQP1 has a role as bio-mechanic sensor modulating and stabilizing the organization of cytoskeleton. In the present paper, we have studied the expression of AQP1 and VEGF pathways in vitro and in tumors xenografts obtained injecting murine (B16-BL6) or human (WM115) melanoma cells in syngeneic or NOD-SCID mice, respectively. All together, our data show the presence of alternative angiogenic pathways in melanoma tumor xenografts and show, for the first time, a connection between AQP1 and VEGF pathway to facilitate vacuolisation and tube formation.
Alternative angiogenic pathways in melanoma: the role of AQP1 / S. Rao, S. De Biasi, L. Cagnoli, C. Clemente, C.A.M. La Porta. - In: JOURNAL OF SOLID TUMORS. - ISSN 1925-4067. - 1:2(2011), pp. 34-43. [10.5430/jst.v1n2p34]
Alternative angiogenic pathways in melanoma: the role of AQP1
S. De Biasi;C.A.M. La Porta
2011
Abstract
AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed preferentially by microvessels, favoring angiogenesis and increasing permeability. Recently, we have demonstrated that AQP1 has a role as bio-mechanic sensor modulating and stabilizing the organization of cytoskeleton. In the present paper, we have studied the expression of AQP1 and VEGF pathways in vitro and in tumors xenografts obtained injecting murine (B16-BL6) or human (WM115) melanoma cells in syngeneic or NOD-SCID mice, respectively. All together, our data show the presence of alternative angiogenic pathways in melanoma tumor xenografts and show, for the first time, a connection between AQP1 and VEGF pathway to facilitate vacuolisation and tube formation.
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