Chronic kidney disease (CKD) affects approximately 500 million people worldwide and is increasingly common in both industrialized and emerging countries. Although the mechanisms underlying the inexorable progression of CKD are incompletely defined, recent discoveries may pave the way to a more comprehensive understanding of the pathophysiology of CKD progression and the development of new therapeutic strategies. In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. The aim of this review is to discuss the links between high blood pressure, proteinuria, phosphate levels, and CKD progression and explore new therapeutic strategies to win the fight against CKD
Blood pressure, proteinuria, and phosphate as risk factors for progressive kidney disease : a hypothesis / M. Cozzolino, G. Gentile, S. Mazzaferro, D. Brancaccio, P. Ruggenenti, G. Remuzzi. - In: AMERICAN JOURNAL OF KIDNEY DISEASES. - ISSN 0272-6386. - 62:5(2013 May), pp. 984-992. [Epub ahead of print] [10.1053/j.ajkd.2013.02.379]
Blood pressure, proteinuria, and phosphate as risk factors for progressive kidney disease : a hypothesis
M. Cozzolino;D. Brancaccio;G. Remuzzi
2013
Abstract
Chronic kidney disease (CKD) affects approximately 500 million people worldwide and is increasingly common in both industrialized and emerging countries. Although the mechanisms underlying the inexorable progression of CKD are incompletely defined, recent discoveries may pave the way to a more comprehensive understanding of the pathophysiology of CKD progression and the development of new therapeutic strategies. In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. The aim of this review is to discuss the links between high blood pressure, proteinuria, phosphate levels, and CKD progression and explore new therapeutic strategies to win the fight against CKDFile | Dimensione | Formato | |
---|---|---|---|
Cozzolino et al AJKD epub.pdf
accesso aperto
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione
538.03 kB
Formato
Adobe PDF
|
538.03 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.