An isocratic reversed-phase liquid chromatographic (HPLC) method is proposed for the practical and reliable determination of triclosan, an antimicrobic agent incorporated into a variety of personal health care products. Chromatographic separations were performed on a C-18 column using acetonitrile-TEA phosphate (70 mM; pH 3.5) 55:45 (v/v) as mobile phase and UV detection at 230 and 280 nm. The selectivity of the method was assured by the on-line photodiode array detector. The identity of the triclosan peak was also confirmed by HPLC MS. The method was successfully applied to the determination of triclosan in commercially available health care products (deodorant stick, dentifrice gel, mouthrinse, toothpaste and handwash). All the products displayed triclosan concentrations in compliance with the EEC directive (less than or equal to 0.3%). (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.

Determination of triclosan in personal health care products by liquid chromatography (HPLC) / A. Piccoli, J. Fiori, V. Andrisano, M. Orioli. - In: IL FARMACO. - ISSN 0014-827X. - 57:5(2002), pp. 369-372.

Determination of triclosan in personal health care products by liquid chromatography (HPLC)

M. Orioli
Ultimo
2002

Abstract

An isocratic reversed-phase liquid chromatographic (HPLC) method is proposed for the practical and reliable determination of triclosan, an antimicrobic agent incorporated into a variety of personal health care products. Chromatographic separations were performed on a C-18 column using acetonitrile-TEA phosphate (70 mM; pH 3.5) 55:45 (v/v) as mobile phase and UV detection at 230 and 280 nm. The selectivity of the method was assured by the on-line photodiode array detector. The identity of the triclosan peak was also confirmed by HPLC MS. The method was successfully applied to the determination of triclosan in commercially available health care products (deodorant stick, dentifrice gel, mouthrinse, toothpaste and handwash). All the products displayed triclosan concentrations in compliance with the EEC directive (less than or equal to 0.3%). (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
Cosmetics; Health care products; Liquid chromatography (HPLC); Triclosan
Settore CHIM/08 - Chimica Farmaceutica
2002
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/210679
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