Clinics and pathology Disease Acute non lymphocytic leukaemia (ANLL) Epidemiology +4 as the sole anomaly is a rare chromosomal abnormality associated with a specific subtype of primary ANLL and secondary (treatment related) ANLL with myelomonocytic morphology; it has been found with the same frequence in the M1-M2 and M4 French-American-British (FAB) phenotypes. Association of +4 with double minute chromosomes has been described in ten cases; five with AML-M2, two with AML-M4, one with refractory anemia with excess of blasts in transformation (RAEB-T), one with chronic myelomonocytic leukemia (CMMoL) and one with unclassified preleukemia. The coincidence of +4 with t(8;21) or its variant t(6;21;8), observed in at least two cases of ANLL (M1 and M2), is therefore recurrent.

+4 or trisomy 4 / A. Beghini. - In: ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY. - ISSN 1768-3262. - 4:3(2000 Jul), pp. 129-130. [10.4267/2042/37648]

+4 or trisomy 4

A. Beghini
Primo
2000

Abstract

Clinics and pathology Disease Acute non lymphocytic leukaemia (ANLL) Epidemiology +4 as the sole anomaly is a rare chromosomal abnormality associated with a specific subtype of primary ANLL and secondary (treatment related) ANLL with myelomonocytic morphology; it has been found with the same frequence in the M1-M2 and M4 French-American-British (FAB) phenotypes. Association of +4 with double minute chromosomes has been described in ten cases; five with AML-M2, two with AML-M4, one with refractory anemia with excess of blasts in transformation (RAEB-T), one with chronic myelomonocytic leukemia (CMMoL) and one with unclassified preleukemia. The coincidence of +4 with t(8;21) or its variant t(6;21;8), observed in at least two cases of ANLL (M1 and M2), is therefore recurrent.
Settore MED/03 - Genetica Medica
lug-2000
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/208976
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