Long-term (7 and 14 days) hypophysectomy resulted in a striking decrease in growth hormone releasing hormone-like immunoreactivity (GHRH-LI) in the median eminence (ME) of adult male rats, evaluated by both radioimmunoassay and immunohistochemistry. Treatment with human GH (125 micrograms/rat, twice daily IP for 14 days) prevented, though partially, depletion of GHRH-LI from the ME, as assessed by both methods. These results demonstrate that circulating GH levels regulate the function of GHRH-producing structures, via a feedback mechanism.
Effect of hypophysectomy and growth hormone replacement on hypothalamic GHRH / I. Ganzetti, V. De Gennaro, M. Redaelli, E.E. Müller, D. Cocchi. - In: PEPTIDES. - ISSN 0196-9781. - 7:6(1986), pp. 1011-1014.
Effect of hypophysectomy and growth hormone replacement on hypothalamic GHRH
V. De GennaroSecondo
;
1986
Abstract
Long-term (7 and 14 days) hypophysectomy resulted in a striking decrease in growth hormone releasing hormone-like immunoreactivity (GHRH-LI) in the median eminence (ME) of adult male rats, evaluated by both radioimmunoassay and immunohistochemistry. Treatment with human GH (125 micrograms/rat, twice daily IP for 14 days) prevented, though partially, depletion of GHRH-LI from the ME, as assessed by both methods. These results demonstrate that circulating GH levels regulate the function of GHRH-producing structures, via a feedback mechanism.Pubblicazioni consigliate
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