Multiple sclerosis (MS) is a demyelinating disorder of unknown etiology, possibly caused by a virus or is virus-triggered. Several viruses, including herpesviruses, were suggested as etiologic agents or risk factors for exacerbation in the course of illness but none have been shown to be irrefutably linked. Recently the interest of researchers and clinicians in the association between viruses and MS was reawakened by the development of progressive multifocal leukoencephalopathy, a demyelinating and fatal disease caused by JC polyomavirus replication, in natalizumab-treated MS patients. In this review, we will illustrate the evidence underlying the viral hypothesis for MS pathogenesis and will review the main features of the potential viral candidates. We will also describe the risks associated with newer MS therapies and with viral/bacterial vaccinations

The long and evolving relationship between viruses and multiple sclerosis / S. DELBUE, S. CARLUCCIO, P. FERRANTE. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - 71:9(2012), pp. 871-883. [10.2217/fvl.12.78]

The long and evolving relationship between viruses and multiple sclerosis

S. Delbue
Primo
;
S. Carluccio
Secondo
;
P. Ferrante
Ultimo
2012

Abstract

Multiple sclerosis (MS) is a demyelinating disorder of unknown etiology, possibly caused by a virus or is virus-triggered. Several viruses, including herpesviruses, were suggested as etiologic agents or risk factors for exacerbation in the course of illness but none have been shown to be irrefutably linked. Recently the interest of researchers and clinicians in the association between viruses and MS was reawakened by the development of progressive multifocal leukoencephalopathy, a demyelinating and fatal disease caused by JC polyomavirus replication, in natalizumab-treated MS patients. In this review, we will illustrate the evidence underlying the viral hypothesis for MS pathogenesis and will review the main features of the potential viral candidates. We will also describe the risks associated with newer MS therapies and with viral/bacterial vaccinations
English
demyelination; environmental factors; herpesviruses; monoclonal antibody; multiple sclerosis; progressive multifocal leukoencephalopathy; risk factors
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
2012
71
9
871
883
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
The long and evolving relationship between viruses and multiple sclerosis / S. DELBUE, S. CARLUCCIO, P. FERRANTE. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - 71:9(2012), pp. 871-883. [10.2217/fvl.12.78]
none
Prodotti della ricerca::01 - Articolo su periodico
3
262
Article (author)
Periodico con Impact Factor
S. Delbue, S. Carluccio, P. Ferrante
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/208294
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