Introduction : Since the introduction of Highly Active Antiretroviral Therapy (HAART), the number of patients dying from AIDS has fallen by more than two thirds. However, treatment causes a number of side effects, especially metabolic problems. Aim of this study was to evaluate fitness and health benefits of fitwalking, as moderate aerobic exercise, with or without strength exercise, in people with HIV infection receiving HAART. Methods : Twenty HIV-infected, HAART-treated, sedentary male subjects performed an outdoor 12-week protocol consisting of 60 min of fitwalking at 65-75% of HRmax, 3 sessions a week. Eight subjects also performed, at each session, 30 min circuit training at 65% of 1RM. Subjects were tested at baseline (BL) and 12 weeks (W12) by: 6 Min Walking Test (6MWT); maximal number of crunches in 30 sec; 1 RM test (lat machine, chest press, leg extension, sitting calf, leg press); general and morphometric examination (heart rate, blood pressure, BMI, waist, hip and leg circumference); blood examination (cytometry, fasting total, HDL and LDL cholesterol, tryglicerides, glucose, insulin; AST/ALT, ALP, gGT, creatinine, CPK, HbA1c; CD4+ lymphocytes and plasma HIV-RNA level). Differences between groups were tested by the Mann-Withney test and differences over time by the Wilcoxon-signed rank test. BL differences between groups; results are expressed as [median (Q1-Q3)]. Results Out of 20 subjects, 18 [49.45 (43.75-54.33) yrs; BMI 24.95 (21.35-26.18) kg/m2] completed the 12-week training protocol and 9 (50%) attended ≥65% of the training sessions. In the whole group, 6MWT distance improved significantly at W12 compared to BL [722.5 (695-830) vs. 675 (627.5-691) m, p=0.002]. At W12 a significant reduction was observed in BMI [24.95 (21.35-26.18) vs. 25.20 (22.71-26.87) kg/m2, p=0.009], waist circumference [92.00 (85.75-96.00) vs. 93.00 (86.25-97.25) cm, p=0.03] and LDL cholesterol [121 (102-135.5) vs. 131 (115-154) mg/dL, p=0.035]. The 8 subjects of the fit-strength group showed a significant increase of strength performance at W12. W12 changes of distance at 6MWT, waist and LDL level did not differ significantly between these subjects and those performing fitwalking only; BMI reduction was more marked in the latter subjects [23.95 (21.08-26.95) vs. 23.89 (21.53-27.13) kg/m2, p=0.054]. Discussion Fitwalking, with or without strength exercise, improved the aerobic fitness, morphometric variables and LDL cholesterol level in HIV-infected treated subjects. It can be offered to these patients to control the side effects of HAART
What are the benefits of physical exercise in people with HIV infection? / M. Bonato, A. La Torre, S. Bossolasco, G. Pavei, G. Merati, L. Galli, P. Cinque - In: Book of Abstracts of the 17th Annual Congress of the European College of Sport Science / [a cura di] R. Meeusen, J. Duchateau, B. Roelands, M. Klass, B. De Geus, S. Baudry, E. Tsolakidis. - [s.l] : European College of Sport Science, 2012 Jul. - ISBN 978-90902686-8-2. - pp. 86-86 (( Intervento presentato al 17. convegno Annual Congress of the-European College of Sport Science tenutosi a Bruges nel 2012.
What are the benefits of physical exercise in people with HIV infection?
M. Bonato;A. La Torre;G. Pavei;G. Merati;L. Galli;
2012
Abstract
Introduction : Since the introduction of Highly Active Antiretroviral Therapy (HAART), the number of patients dying from AIDS has fallen by more than two thirds. However, treatment causes a number of side effects, especially metabolic problems. Aim of this study was to evaluate fitness and health benefits of fitwalking, as moderate aerobic exercise, with or without strength exercise, in people with HIV infection receiving HAART. Methods : Twenty HIV-infected, HAART-treated, sedentary male subjects performed an outdoor 12-week protocol consisting of 60 min of fitwalking at 65-75% of HRmax, 3 sessions a week. Eight subjects also performed, at each session, 30 min circuit training at 65% of 1RM. Subjects were tested at baseline (BL) and 12 weeks (W12) by: 6 Min Walking Test (6MWT); maximal number of crunches in 30 sec; 1 RM test (lat machine, chest press, leg extension, sitting calf, leg press); general and morphometric examination (heart rate, blood pressure, BMI, waist, hip and leg circumference); blood examination (cytometry, fasting total, HDL and LDL cholesterol, tryglicerides, glucose, insulin; AST/ALT, ALP, gGT, creatinine, CPK, HbA1c; CD4+ lymphocytes and plasma HIV-RNA level). Differences between groups were tested by the Mann-Withney test and differences over time by the Wilcoxon-signed rank test. BL differences between groups; results are expressed as [median (Q1-Q3)]. Results Out of 20 subjects, 18 [49.45 (43.75-54.33) yrs; BMI 24.95 (21.35-26.18) kg/m2] completed the 12-week training protocol and 9 (50%) attended ≥65% of the training sessions. In the whole group, 6MWT distance improved significantly at W12 compared to BL [722.5 (695-830) vs. 675 (627.5-691) m, p=0.002]. At W12 a significant reduction was observed in BMI [24.95 (21.35-26.18) vs. 25.20 (22.71-26.87) kg/m2, p=0.009], waist circumference [92.00 (85.75-96.00) vs. 93.00 (86.25-97.25) cm, p=0.03] and LDL cholesterol [121 (102-135.5) vs. 131 (115-154) mg/dL, p=0.035]. The 8 subjects of the fit-strength group showed a significant increase of strength performance at W12. W12 changes of distance at 6MWT, waist and LDL level did not differ significantly between these subjects and those performing fitwalking only; BMI reduction was more marked in the latter subjects [23.95 (21.08-26.95) vs. 23.89 (21.53-27.13) kg/m2, p=0.054]. Discussion Fitwalking, with or without strength exercise, improved the aerobic fitness, morphometric variables and LDL cholesterol level in HIV-infected treated subjects. It can be offered to these patients to control the side effects of HAART
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