Four patients with heavy menorrhagia, severe iron-deficiency anemia and contraindications to surgery were treated with a gonadotropin-releasing hormone agonist in a depot formulation. At 2 months of therapy they were all amenorrheic, and at 6 months the hematologic values had improved markedly. Gonadotropin-releasing hormone agonists may obviate emergency surgery in patients at high surgical risk or could constitute the first line of sequential therapeutic regimens, once general health conditions have improved.
Gonadotropin releasing hormone agonist treatment for severe menorrhagia in patients with contraindications to surgery / P. Vercellini, A. Ferrari, A. D'Alberton, T. Motta, R. Maggi, P. Molteni. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 45:1(1992 Jun 16), pp. 70-72. [10.1016/0028-2243(92)90197-7]
Gonadotropin releasing hormone agonist treatment for severe menorrhagia in patients with contraindications to surgery
P. Vercellini;T. Motta;
1992
Abstract
Four patients with heavy menorrhagia, severe iron-deficiency anemia and contraindications to surgery were treated with a gonadotropin-releasing hormone agonist in a depot formulation. At 2 months of therapy they were all amenorrheic, and at 6 months the hematologic values had improved markedly. Gonadotropin-releasing hormone agonists may obviate emergency surgery in patients at high surgical risk or could constitute the first line of sequential therapeutic regimens, once general health conditions have improved.
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