The genes encoding angiotensin converting enzyme (ACE, I/D), alpha-adducin (ADD, Gly460Trp) and aldosterone synthase (AS, -344C/T) share the potential of influencing blood pressure (BP) via sodium homeostasis. However, most studies in humans focused on single-gene effects and disregarded epistasis, the suppression or potentiation of a gene by other non-allelic genes.
Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population / J.A. Staessen, J.G. Wang, E. Brand, C. Barlassina, W.H. Birkenhäger, S.M. Herrmann, R. Fagard, L. Tizzoni, G. Bianchi. - In: JOURNAL OF HYPERTENSION. - ISSN 0263-6352. - 19:8(2001 Aug), pp. 1349-1358.
Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population
C. Barlassina;
2001
Abstract
The genes encoding angiotensin converting enzyme (ACE, I/D), alpha-adducin (ADD, Gly460Trp) and aldosterone synthase (AS, -344C/T) share the potential of influencing blood pressure (BP) via sodium homeostasis. However, most studies in humans focused on single-gene effects and disregarded epistasis, the suppression or potentiation of a gene by other non-allelic genes.
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