β-Endorphin (β-EP) and cholecystokinin 8 (CCK-8) concentrations in peripheral blood mononuclear cells were measured in 12 drug-free autistic (AU) children, in 10 drug-free children with pervasive developmental disorders (PDD) and in 11 healthy controls. The aim of the study was to see whether or not there was an alteration of β-EP and CCK-8 concentrations in this peripheral compartment, in which it has been suggested that secretion and regulation of the two peptides mimic those of neurons in the central nervous system. Mean β-EP values were significantly higher in AU than in PDD and control children, while there were no differences in CCK-8 values of the three groups.
Beta-endorphin and cholecystokinin-8 concentrations in peripheral blood mononuclear cells of autistic children / F. BRAMBILLA, A. GUARESCHI CAZZULLO, C. TACCHINI, C. MUSETTI, A.E. PANERAI, P. SACERDOTE. - In: NEUROPSYCHOBIOLOGY. - ISSN 0302-282X. - 35:1(1997), pp. 1-4.
Beta-endorphin and cholecystokinin-8 concentrations in peripheral blood mononuclear cells of autistic children
C. MUSETTI;A.E. PANERAIPenultimo
;P. SACERDOTEUltimo
1997
Abstract
β-Endorphin (β-EP) and cholecystokinin 8 (CCK-8) concentrations in peripheral blood mononuclear cells were measured in 12 drug-free autistic (AU) children, in 10 drug-free children with pervasive developmental disorders (PDD) and in 11 healthy controls. The aim of the study was to see whether or not there was an alteration of β-EP and CCK-8 concentrations in this peripheral compartment, in which it has been suggested that secretion and regulation of the two peptides mimic those of neurons in the central nervous system. Mean β-EP values were significantly higher in AU than in PDD and control children, while there were no differences in CCK-8 values of the three groups.
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