Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease(1,2) and is reduced in schizophrenia(3), major depression(4) and mesial temporal lobe epilepsy(5). Whereas many brain imaging phenotypes are highly heritable(6,7), identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 x 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 x 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 x 10(-7)).
Identification of common variants associated with human hippocampal and intracranial volumes / J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, R.E. Senstad, A.M. Winkler, R. Toro, K. Appel, R. Bartecek, O. Bergmann, M. Bernard, A.A. Brown, D.M. Cannon, M.M. Chakravarty, A. Christoforou, M. Domin, O. Grimm, M. Hollinshead, A.J. Holmes, G. Homuth, J. Hottenga, C. Langan, L.M. Lopez, N.K. Hansell, K.S. Hwang, S. Kim, G. Laje, P.H. Lee, X. Liu, E. Loth, A. Lourdusamy, M. Mattingsdal, S. Mohnke, S.M. Maniega, K. Nho, A.C. Nugent, C. O'Brien, M. Papmeyer, B. Putz, A. Ramasamy, J. Rasmussen, M. Rijpkema, S.L. Risacher, J.C. Roddey, E.J. Rose, M. Ryten, L. Shen, E. Sprooten, E. Strengman, A. Teumer, D. Trabzuni, J. Turner, K. Eijk, T.G.M. Erp, M. Tol, K. Wittfeld, C. Wolf, S. Woudstra, A. Aleman, S. Alhusaini, L. Almasy, E.B. Binder, D.G. Brohawn, R.M. Cantor, M.A. Carless, A. Corvin, M. Czisch, J.E. Curran, G. Davies, M.A.A. Almeida, N. Delanty, C. Depondt, R. Duggirala, T.D. Dyer, S. Erk, J. Fagerness, P.T. Fox, N.B. Freimer, M. Gill, H.H.H. Goering, D.J. Hagler, D. Hoehn, F. Holsboer, M. Hoogman, N. Hosten, N. Jahanshad, M.P. Johnson, D. Kasperaviciute, J.W. Kent, P. Kochunov, J.L. Lancaster, S.M. Lawrie, D.C. Liewald, R. Mandl, M. Matarin, M. Mattheisen, E. Meisenzahl, I. Melle, E.K. Moses, T.W. Muehleisen, M. Nauck, M.M. Noethen, R.L. Olvera, M. Pandolfo, G.B. Pike, R. Puls, I. Reinvang, M.E. Renteria, M. Rietschel, J.L. Roffman, N.A. Royle, D. Rujescu, J. Savitz, H.G. Schnack, K. Schnell, N. Seiferth, C. Smith, V.M. Steen, M.C.V. Hernandez, M. Heuvel, N.J. Wee, N.E.M. Van Haren, J.A. Veltman, H. Voelzke, R. Walker, L.T. Westlye, C.D. Whelan, I. Agartz, D.I. Boomsma, G.L. Cavalleri, A.M. Dale, S. Djurovic, W.C. Drevets, P. Hagoort, J. Hall, A. Heinz, C.R. Jack, T.M. Foroud, S. Le Hellard, F. Macciardi, G.W. Montgomery, J.B. Poline, D.J. Porteous, S.M. Sisodiya, J.M. Starr, J. Sussmann, A.W. Toga, D.J. Veltman, H. Walter, M.W. Weiner, J.C. Bis, M.A. Ikram, A.V. Smith, V. Gudnason, C. Tzourio, M.W. Vernooij, L.J. Launer, C. DeCarli, S. Seshadri, O.A. Andreassen, L.G. Apostolova, M.E. Bastin, J. Blangero, H.G. Brunner, R.L. Buckner, S. Cichon, G. Coppola, G.I. Zubicaray, I.J. Deary, G. Donohoe, E.J.C. Geus, T. Espeseth, G. Fernandez, D.C. Glahn, H.J. Grabe, J. Hardy, H.E.H. Pol, M. Jenkinson, R.S. Kahn, C. McDonald, A.M. McIntosh, F.J. McMahon, K.L. McMahon, A. Meyer-Lindenberg, D.W. Morris, B. Mueller-Myhsok, T.E. Nichols, R.A. Ophoff, T. Paus, Z. Pausova, B.W. Penninx, S.G. Potkin, P.G. Saemann, A.J. Saykin, G. Schumann, J.W. Smoller, J.M. Wardlaw, M.E. Weale, N.G. Martin, B. Franke, M.J. Wright, P.M. Thompson, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:5(2012), pp. 552-561.
Identification of common variants associated with human hippocampal and intracranial volumes
F. Macciardi;
2012
Abstract
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease(1,2) and is reduced in schizophrenia(3), major depression(4) and mesial temporal lobe epilepsy(5). Whereas many brain imaging phenotypes are highly heritable(6,7), identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 x 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 x 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 x 10(-7)).
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