The enantioselective oxidation of (RS)-2-phenyl-1-propanol to (S)-2-phenylpropionic acid catalysed by Acetobacter aceti occurred under very mild conditions. The rate, substrate tolerance and enantioselectivity (enantiomeric ratio, E >200) can be increased dramatically simply by adding cyclodextrins to the reaction medium. Cells immobilized in calcium alginate showed good operational stability and good enantioselectivity (e.e. 94%); the catalyst can be re-used at least five times without e.e. diminution.
Enantioselective oxidation of (±)-2-phenyl-1-propanol to (S)-2-phenyl-1-propionic acid with Acetobacter aceti: influence of medium engineering and immobilization / R. Gandolfi, A. Borrometi, A. Romano, J.V. Sinisterra Gago, F.E. Molinari. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 13:21(2002), pp. 2345-2349. [10.1016/S0957-4166(02)00641-9]
Enantioselective oxidation of (±)-2-phenyl-1-propanol to (S)-2-phenyl-1-propionic acid with Acetobacter aceti: influence of medium engineering and immobilization
R. GandolfiPrimo
;A. Romano;F.E. MolinariUltimo
2002
Abstract
The enantioselective oxidation of (RS)-2-phenyl-1-propanol to (S)-2-phenylpropionic acid catalysed by Acetobacter aceti occurred under very mild conditions. The rate, substrate tolerance and enantioselectivity (enantiomeric ratio, E >200) can be increased dramatically simply by adding cyclodextrins to the reaction medium. Cells immobilized in calcium alginate showed good operational stability and good enantioselectivity (e.e. 94%); the catalyst can be re-used at least five times without e.e. diminution.
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