We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)-deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)-a and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF-a, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF-a and a decrease in EGF-levels.

High tumor necrosis factor-alpha levels in cerebrospinal fluid of cobalamin-deficient patients / G. Scalabrino, M. Carpo, F. Bamonti, S. Pizzinelli, C. D’Avino, N. Bresolin, G. Meucci, V. Martinelli, G. Comi, M. Peracchi. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 56:6(2004 Dec), pp. 886-890. [10.1002/ana.20325]

High tumor necrosis factor-alpha levels in cerebrospinal fluid of cobalamin-deficient patients

G. Scalabrino
Primo
;
M. Carpo
Secondo
;
F. Bamonti;N. Bresolin;G. Comi
Penultimo
;
M. Peracchi
Ultimo
2004

Abstract

We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)-deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)-a and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF-a, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF-a and a decrease in EGF-levels.
EPIDERMAL-GROWTH-FACTOR ; NEUROTROPHIC ACTION; NERVOUS-SYSTEM ; SPINAL-CORD ; BRAIN ; VITAMIN-B-12 ; RATS
Settore MED/04 - Patologia Generale
Settore MED/26 - Neurologia
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
dic-2004
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/20143
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