We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)-deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)-a and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF-a, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF-a and a decrease in EGF-levels.
High tumor necrosis factor-alpha levels in cerebrospinal fluid of cobalamin-deficient patients / G. Scalabrino, M. Carpo, F. Bamonti, S. Pizzinelli, C. D’Avino, N. Bresolin, G. Meucci, V. Martinelli, G. Comi, M. Peracchi. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 56:6(2004 Dec), pp. 886-890. [10.1002/ana.20325]
High tumor necrosis factor-alpha levels in cerebrospinal fluid of cobalamin-deficient patients
G. ScalabrinoPrimo
;M. CarpoSecondo
;F. Bamonti;N. Bresolin;G. ComiPenultimo
;M. PeracchiUltimo
2004
Abstract
We studied 14 patients with neurological manifestations of subacute combined degeneration (SCD) and 40 control patients not cobalamin (Cbl)-deficient. The cerebrospinal fluid (CSF) markers of Cbl deficiency (Cbl and total homocysteine [tHCYS] levels) and the CSF levels of tumor necrosis factor (TNF)-a and epidermal growth factor (EGF) were measured. Significantly higher levels of tHCYS and TNF-a, and significantly lower levels of Cbl and EGF were found in the SCD patients. In human CSF, as in human serum and the rat central nervous system, decreased Cbl concentrations are concomitant with an increase in TNF-a and a decrease in EGF-levels.Pubblicazioni consigliate
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