Tissue engineering represents an innovative approach for the treatment of severe bone defects in which cells and scaffolds are used for restoring or repairing damage tissues. Adipose-derived stem cells (ASCs) may represent, alone or in association with osteoconductive scaffolds, an efficient approach for bone regeneration. In this study, autologous ASCs were re-implanted in a full-thickness bone defect in the rabbit’s tibia. Animals have been divided in 4 groups: group treated with bio-construct ASCs-hydroxyapatite disk (ASCs-HA), with ASCs or HA alone, and untreated group. Each ASCs population was tested in vitro for evaluate their ability to osteo-differentiate. 8-weeks after surgery, in ASCs-HA treated defects, new bone tissue was observed along the walls and in the inner part of the pores with a mature lamellar conformation and with biomechanical properties similar to the native bone tissue concluding that autologous ASCs-HA construct may be a promising treatment for critical bone defects
Preclinical studies with autologous adipose-derived stem cells (ASCs) in regenerative medicine for orthopaedic applications / E. Arrigoni, L. de Girolamo, A. Di Giancamillo, D. Stanco, S. Niada, V.A. Yenagi, C. Domeneghini, A.T. Brini - In: Proceeding of 2. international conference on tissue engineering / [a cura di] P.R. Fernandes, P.J. Bartolo, J. Folgado, H.C. Rodrigues, R.B. Ruben, H. Almeida, M.R. Dias. - 2. ed. - [s.l] : IST Press, 2011. - ISBN 978-989-8481-02-3. - pp. 143-148 (( Intervento presentato al 2. convegno International Conference on Tissue Engineering (ICTE) tenutosi a Lisbon nel 2011.
Preclinical studies with autologous adipose-derived stem cells (ASCs) in regenerative medicine for orthopaedic applications
E. Arrigoni;L. de Girolamo;A. Di Giancamillo;D. Stanco;S. Niada;V.A. Yenagi;C. Domeneghini;A.T. Brini
2011
Abstract
Tissue engineering represents an innovative approach for the treatment of severe bone defects in which cells and scaffolds are used for restoring or repairing damage tissues. Adipose-derived stem cells (ASCs) may represent, alone or in association with osteoconductive scaffolds, an efficient approach for bone regeneration. In this study, autologous ASCs were re-implanted in a full-thickness bone defect in the rabbit’s tibia. Animals have been divided in 4 groups: group treated with bio-construct ASCs-hydroxyapatite disk (ASCs-HA), with ASCs or HA alone, and untreated group. Each ASCs population was tested in vitro for evaluate their ability to osteo-differentiate. 8-weeks after surgery, in ASCs-HA treated defects, new bone tissue was observed along the walls and in the inner part of the pores with a mature lamellar conformation and with biomechanical properties similar to the native bone tissue concluding that autologous ASCs-HA construct may be a promising treatment for critical bone defects
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