A series of 24 lung cancer cases was studied: 12 epidermoid carcinomas, 9 adenocarcinomas, 2 giant-cell carcinomas and 1 carcinoid. The patients were staged on the basis of the TNM classification system as 9 stage I, 5 stage II, 9 stage III and 1 stage IV. Using fresh tumour cell samples 2 cell cultures were prepared for each patient: one to identify the percentage of S phase cells (Labelling Index) using the tritiated thymidine method and one for cytogenetic analysis. A gentic map was obtained in 6 cases and revealed no specific numerical or structural alterations. The Labelling Index (L.I.) was calculated for all patients and compared with all TNM parameters. This revealed a certain connection between L.I. and parameters T, SN and G but no link with parameters.

[Clinical significance of cell kinetics in lung cancer] / F. Grignani, F. Varoli, A.M. Lavezzi, S.M. Scalambra, C. Vergani, L. Maturri, G.C. Roviaro. - In: MINERVA MEDICA. - ISSN 0026-4806. - 80:3(1989 Mar), pp. 195-197.

[Clinical significance of cell kinetics in lung cancer]

F. Varoli
Secondo
;
A.M. Lavezzi;C. Vergani;G.C. Roviaro
Ultimo
1989

Abstract

A series of 24 lung cancer cases was studied: 12 epidermoid carcinomas, 9 adenocarcinomas, 2 giant-cell carcinomas and 1 carcinoid. The patients were staged on the basis of the TNM classification system as 9 stage I, 5 stage II, 9 stage III and 1 stage IV. Using fresh tumour cell samples 2 cell cultures were prepared for each patient: one to identify the percentage of S phase cells (Labelling Index) using the tritiated thymidine method and one for cytogenetic analysis. A gentic map was obtained in 6 cases and revealed no specific numerical or structural alterations. The Labelling Index (L.I.) was calculated for all patients and compared with all TNM parameters. This revealed a certain connection between L.I. and parameters T, SN and G but no link with parameters.
Neoplasm Staging; Humans; Prognosis; Aged; Interphase; Carcinoma, Small Cell; Lung Neoplasms; Adult; Carcinoid Tumor; Follow-Up Studies; Middle Aged; Adenocarcinoma; Carcinoma, Squamous Cell; Cell Cycle
Settore MED/18 - Chirurgia Generale
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore MED/21 - Chirurgia Toracica
Settore MED/06 - Oncologia Medica
mar-1989
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/196789
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