An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stercoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. (C) 2002 Elsevier Science Ltd. All rights reserved.

Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, A. Puglisi. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 10:6(2002), pp. 1813-1818.

Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen

R. Annunziata
Primo
;
M. Benaglia
Secondo
;
M. Cinquini;F. Cozzi
Penultimo
;
A. Puglisi
Ultimo
2002

Abstract

An efficient synthesis of a beta-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stercoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. (C) 2002 Elsevier Science Ltd. All rights reserved.
Settore CHIM/06 - Chimica Organica
2002
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/193717
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