A new series of N-substituted-3-[1-alkyl(aryl)-4-piperidyl]azetidin-2- ones 2a-j structurally related to the previously reported 2,7- diazaspiro[3,5]nonan-1-ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo. Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.
Synthesis of a new series of N-substituted-3(1-alkyl/aryl-4-piperidyl)azetidin-2-ones as possible muscarinic agents / G. Cignarella, S. Villa, D. Barlocco. - In: JOURNAL OF HETEROCYCLIC CHEMISTRY. - ISSN 0022-152X. - 30:5(1993), pp. 1337-1340. [10.1002/jhet.5570300526]
Synthesis of a new series of N-substituted-3(1-alkyl/aryl-4-piperidyl)azetidin-2-ones as possible muscarinic agents
G. Cignarella;S. VillaSecondo
;D. BarloccoUltimo
1993
Abstract
A new series of N-substituted-3-[1-alkyl(aryl)-4-piperidyl]azetidin-2- ones 2a-j structurally related to the previously reported 2,7- diazaspiro[3,5]nonan-1-ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo. Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.Pubblicazioni consigliate
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