The fibrinolytic system is regulated by the balance between the levels of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor l (P AI-l). Disturbances of the fibrinolytic system has been described in many atherotrombotic conditions, due, in part to the interaction of fibrinolytic variables with lipoproteins and/or insulin or insulin like peptides. In this study we have investigated the relationship between fasting levels of lipids, insulin an d fibrinolytic variables in normo (NTG) and hypertriglyceridemic (HTG) subjects attending a Lipid Clinic. P AI-l and t-PA antigen were higher in HTG than in NTG subjects. In the multivariate analysis several significant correlations between fibrinolytic and metabolic variables were found. At the stepwise multiple regression analysis, however, triglycerides were the only main predictor of t-PA (r2=0.13, p<0.0001) whereas both insulin and triglycerides were significant and independent predictors of PAI-1 antigen levels (r2=0.22, p<0.0001). To investigate the relationship between triglycerides, insulin and PAI-1 the subjects w ere then categorized in tertiles according to their levels of TG and insulin. PAI-1 antigen levels gradually increased with rising levels of TG within al! strata of insulin. In contrast the increase of PAI-1 with rising of insulin levels was evident in the highest tertile of triglycerides only. In addition, subjects in the lowest tertile of TG and insulin had the lowest PAI-1 antigen levels, while subjects in the highest tertiles of TG and insulin had the highest levels of PAI-1. This study indicates that triglycerides is the only independent predictor of t-PA antigen levels, whereas triglyceride and insulin are independent predictors of PAI-1 antigen levels.

Triglycerides as predictor of tissue activator and of tissue plasminogen activator inhibitor type 1 levels in non obese normo and hypertriglyceridemic subjects / L. Mussoni, D. Baldassarre, L. Mannucci, C. Sirtori, E. Tremoli. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 135:1(1997), pp. S17-S17. ((Intervento presentato al 11. convegno 11° Congresso Nazionale della Società Italiana per lo Studio dell’Arteriosclerosi tenutosi a Vibo Valentia, Italia nel 1997.

Triglycerides as predictor of tissue activator and of tissue plasminogen activator inhibitor type 1 levels in non obese normo and hypertriglyceridemic subjects

L. Mussoni
Primo
;
D. Baldassarre
Secondo
;
C. Sirtori
Penultimo
;
E. Tremoli
Ultimo
1997

Abstract

The fibrinolytic system is regulated by the balance between the levels of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor l (P AI-l). Disturbances of the fibrinolytic system has been described in many atherotrombotic conditions, due, in part to the interaction of fibrinolytic variables with lipoproteins and/or insulin or insulin like peptides. In this study we have investigated the relationship between fasting levels of lipids, insulin an d fibrinolytic variables in normo (NTG) and hypertriglyceridemic (HTG) subjects attending a Lipid Clinic. P AI-l and t-PA antigen were higher in HTG than in NTG subjects. In the multivariate analysis several significant correlations between fibrinolytic and metabolic variables were found. At the stepwise multiple regression analysis, however, triglycerides were the only main predictor of t-PA (r2=0.13, p<0.0001) whereas both insulin and triglycerides were significant and independent predictors of PAI-1 antigen levels (r2=0.22, p<0.0001). To investigate the relationship between triglycerides, insulin and PAI-1 the subjects w ere then categorized in tertiles according to their levels of TG and insulin. PAI-1 antigen levels gradually increased with rising levels of TG within al! strata of insulin. In contrast the increase of PAI-1 with rising of insulin levels was evident in the highest tertile of triglycerides only. In addition, subjects in the lowest tertile of TG and insulin had the lowest PAI-1 antigen levels, while subjects in the highest tertiles of TG and insulin had the highest levels of PAI-1. This study indicates that triglycerides is the only independent predictor of t-PA antigen levels, whereas triglyceride and insulin are independent predictors of PAI-1 antigen levels.
Settore BIO/14 - Farmacologia
1997
Article (author)
File in questo prodotto:
File Dimensione Formato  
musson triglycerides asi vibo.PDF

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 4.64 MB
Formato Adobe PDF
4.64 MB Adobe PDF Visualizza/Apri
musson triglycerides asi vibo.PDF

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 4.64 MB
Formato Adobe PDF
4.64 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/192392
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact