(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes. (C) 2002 Published by Elsevier Science Ltd.
A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins / F. Orsini, G. Sello, E. Travaini, P. Di Gennaro. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 13:3(2002), pp. 253-259. [10.1016/S0957-4166(02)00098-8]
A chemoenzymatic synthesis of (2R)-8-substituted-2-aminotetralins
F. Orsini;G. Sello;P. Di Gennaro
2002
Abstract
(2R)-2-Amino-8-methoxy-1,2,3,4-tetrahydronaphthalene, a useful precursor of the 5-hydroxytryptamine receptor agonist 8-OH-DPAT((2R)-2-(dipropylamino)-8-hydroxytetrahydronaphthalene), has been synthesized from 1-methoxynaphthalene through a chemoenzymatic protocol. The same protocol has been subsequently applied to the synthesis of other (2R)-2-amino-1,2,3,4-tetrahydronaphthalenes. (C) 2002 Published by Elsevier Science Ltd.
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