Beta-interferon was administered by intravenous infusion to 16 patients affected with fulminant hepatitis B virus infection in third or fourth-grade coma. Ten patients presented a superinfection or a co-infection due to the delta (delta)-agent. None had detectable interferon (IFN) activity before therapy was begun. Besides fever, no significant side-effects were observed during treatment. Both the IFN-treated group as well as the "historical" control group, made up of 70 cases of fulminant virus hepatitis, not treated with IFN and observed during a previous ten year-period, received supportive therapy; survival rates were similar in both groups. Furthermore, the presence or absence of the delta-agent did not appear to affect survival rates significantly.
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon / F. Milazzo, M. Galli, P. G. Fassio, A. Cargnel, A. Pugliese, P. A. Tovo, G. M. Vigevani, R. Esposito, A. Lazzarin, F. Caredda. - In: INFECTION. - ISSN 0300-8126. - 13:3(1985), pp. 130-133.
Attempted treatment of fulminant viral hepatitis with human fibroblast interferon
M. GalliSecondo
;A. LazzarinPenultimo
;
1985
Abstract
Beta-interferon was administered by intravenous infusion to 16 patients affected with fulminant hepatitis B virus infection in third or fourth-grade coma. Ten patients presented a superinfection or a co-infection due to the delta (delta)-agent. None had detectable interferon (IFN) activity before therapy was begun. Besides fever, no significant side-effects were observed during treatment. Both the IFN-treated group as well as the "historical" control group, made up of 70 cases of fulminant virus hepatitis, not treated with IFN and observed during a previous ten year-period, received supportive therapy; survival rates were similar in both groups. Furthermore, the presence or absence of the delta-agent did not appear to affect survival rates significantly.Pubblicazioni consigliate
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