Six groups of 16 rats each were fed a standard diet for 8 weeks. Aluminium (Al) complexed with organic anions (citrate, lactate, malate, or tartrate) was added to the diet of four of the groups and aluminium hydroxide to the diet of one group (control 'Al +'). Aluminium concentrations in the diets were 1500-2000 mg/kg. The sixth group (control 'Al -') served as control. Plasma, bone (femur), kidneys, cerebral cortex and cerebellum levels of aluminium were determined at 4 and 8 weeks. All the complexing agents increased tissue accumulations, compared with values in the two control groups, especially citrate in bone and kidneys and lactate in cerebral cortex. There were no significant differences (P < 0.05) in aluminium levels in the tissues considered between the 'Al +' and 'Al -' control groups. Our results show the ability of dietary organic acids to increase aluminium absorption and tissue accumulation and indicate that concurrent intake of aluminium and dietary organic acids is not appropriate.

Influence of organic acids on aluminium absorption and storage in rat tissues / G. Testolin, D. Erba, S. Ciappellano, G. Bermano. - In: FOOD ADDITIVES AND CONTAMINANTS. - ISSN 0265-203X. - 13:1(1996 Jan), pp. 21-7-27.

Influence of organic acids on aluminium absorption and storage in rat tissues

G. Testolin
Primo
;
D. Erba
Secondo
;
S. Ciappellano
Penultimo
;
1996

Abstract

Six groups of 16 rats each were fed a standard diet for 8 weeks. Aluminium (Al) complexed with organic anions (citrate, lactate, malate, or tartrate) was added to the diet of four of the groups and aluminium hydroxide to the diet of one group (control 'Al +'). Aluminium concentrations in the diets were 1500-2000 mg/kg. The sixth group (control 'Al -') served as control. Plasma, bone (femur), kidneys, cerebral cortex and cerebellum levels of aluminium were determined at 4 and 8 weeks. All the complexing agents increased tissue accumulations, compared with values in the two control groups, especially citrate in bone and kidneys and lactate in cerebral cortex. There were no significant differences (P < 0.05) in aluminium levels in the tissues considered between the 'Al +' and 'Al -' control groups. Our results show the ability of dietary organic acids to increase aluminium absorption and tissue accumulation and indicate that concurrent intake of aluminium and dietary organic acids is not appropriate.
Tartrates; Animals; Food, Formulated; Citric Acid; Lactic Acid; Tissue Distribution; Citrates; Rats; Rats, Sprague-Dawley; Lactates; Malates; Aluminum; Absorption; Female
Settore BIO/09 - Fisiologia
gen-1996
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/189342
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 0
social impact