Aberrations of the p53 gene (also known as TP53) frequently lead to the synthesis of mutant proteins that accumulate in the nuclei and/or cytoplasm of neoplastic cells. Intracellular p53 protein accumulation may be an unfavorable prognostic parameter in breast, lung, ovarian, gastric, and colorectal cancers. Specific classes of p53 gene mutations, assayed by characteristic subcellular p53 protein accumulation patterns, may be useful prognostic indicators.
Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas / S. Bosari, G. Viale, P. Bossi, M. Maggioni, G. Coggi, J. J. Murray, A. K. Lee. - In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - ISSN 0027-8874. - 86:9(1994 May 04), pp. 681-687. [10.1093/jnci/86.9.681]
Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas
S. BosariPrimo
;G. VialeSecondo
;
1994
Abstract
Aberrations of the p53 gene (also known as TP53) frequently lead to the synthesis of mutant proteins that accumulate in the nuclei and/or cytoplasm of neoplastic cells. Intracellular p53 protein accumulation may be an unfavorable prognostic parameter in breast, lung, ovarian, gastric, and colorectal cancers. Specific classes of p53 gene mutations, assayed by characteristic subcellular p53 protein accumulation patterns, may be useful prognostic indicators.
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