The effect of stent coatings in preventing early thrombotic occlusion remains to be proved. The purpose of this study was to evaluate the safety and efficacy of the Carbostent, a new coronary stent with a nonthrombogenic coating (Carbofilm), in 110 consecutive patients (73.6% men, mean age 61 +/- 9 years) who met prespecified clinical and angiographic inclusion criteria and were treated with aspirin monotherapy after stenting. Stable angina (75.5%), unstable angina (18.2%), and silent ischemia (6.3%) were clinical indications for coronary revascularization. Patients received 10,000 U of heparin and no IIb/IIIa inhibitors or postprocedural heparin. Complex lesion characteristics (B2, C) were present in 39 out of 129 (30.2%) lesions. Mean lesion length was 15.6 +/- 7.4 mm, and 32% of the lesions were >15 mm (range 16-52 mm). Small coronary vessels (<3.0 mm) were treated in 28% of the cases. A total of 165 Carbostent were used in 129 coronary lesions of the 110 patients. Single-vessel stenting was performed in 97 (88%) patients and multivessel stent placement in 13 (12%) patients. The mean length of the stented segment was 21 +/- 13 mm (range 9-95 mm). Procedural and clinical success was achieved in all patients. At 1-month follow-up, there were no stent thrombosis or other major adverse cardiac events. We observed 2 (1.8%) non-Q-wave myocardial infarctions and 2 (1.8%) vascular complications. This study indicates that the Carbostent may prevent stent thrombosis in selected patients treated with aspirin only. A randomized study comparing aspirin alone versus combined ticlopidine and aspirin after Carbostent implantation will be needed to confirm these results.
|Titolo:||Aspirin alone antiplatelet regimen after intracoronary placement of the Carbostent: the ANTARES study|
|Parole Chiave:||Arterial Occlusive Diseases; Ticlopidine; Humans; Coronary Angiography; Aged; Pilot Projects; Italy; Coronary Disease; Drug Therapy, Combination; Carbon; Postoperative Complications; Aspirin; Adult; Treatment Outcome; Blood Vessel Prosthesis Implantation; Stainless Steel; Platelet Aggregation Inhibitors; Middle Aged; Stents; Follow-Up Studies; Time Factors; Male; Coated Materials, Biocompatible; Female|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||feb-2002|
|Digital Object Identifier (DOI):||10.1002/ccd.10037|
|Appare nelle tipologie:||01 - Articolo su periodico|