A series of dinitro and monoamino-mononitro analogues of the 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.
5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the ACAT inhibitor 5,6-diphenyl-3-alkylaminopyridazines / L. Toma, D. Nava, G. Celentano, M.P. Giovannoni, V. Dal Piaz, B.M. Kwon, M.K. Kim, Y.K. Kim, D. Barlocco. - In: HETEROCYCLES. - ISSN 0385-5414. - 53:12(2000), pp. 2709-2718.
5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the ACAT inhibitor 5,6-diphenyl-3-alkylaminopyridazines
D. NavaSecondo
;G. Celentano;D. BarloccoUltimo
2000
Abstract
A series of dinitro and monoamino-mononitro analogues of the 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.
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