Chiral allylic secondary alcohols have been resolved efficiently by catalytic hydrogenation with ruthenium complexes derived from the new chiral atropisomeric (R)- and (S)-BITIANP. These catalytic sistems have been applied to the resolution of NCS-382, a selective antagonist of the γ-hydroxybutyric acid (GHB) receptors. NCS-382 may play a role as a central neuromodulator and possesses several neuropharmacological properties that can be investigated in detail only if both entomer and distomer are available in bulk. Copyright (C) 2000 John Wiley and Sons, Ltd.
Kinetic resolution of chiral racemic alcohols by BITIANP-ruthenium(II)-catalyzed hydrogenation / E. Cesarotti, S. Araneo, D. Berta. - In: APPLIED ORGANOMETALLIC CHEMISTRY. - ISSN 0268-2605. - 14:11(2000), pp. 735-738.
Kinetic resolution of chiral racemic alcohols by BITIANP-ruthenium(II)-catalyzed hydrogenation
E. CesarottiPrimo
;S. AraneoSecondo
;
2000
Abstract
Chiral allylic secondary alcohols have been resolved efficiently by catalytic hydrogenation with ruthenium complexes derived from the new chiral atropisomeric (R)- and (S)-BITIANP. These catalytic sistems have been applied to the resolution of NCS-382, a selective antagonist of the γ-hydroxybutyric acid (GHB) receptors. NCS-382 may play a role as a central neuromodulator and possesses several neuropharmacological properties that can be investigated in detail only if both entomer and distomer are available in bulk. Copyright (C) 2000 John Wiley and Sons, Ltd.
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