beta -Enamino keto ester (2a) reacts with hydroxylamine to give an isoxazole derivative (3). Compound (2a) reacts with hydrazine, alkyl- and arylhydrazines to give pyrazole derivatives (4a-e) as only reaction products. Methylation of compound (4a) afforded the two isomeric pyrazole derivatives (4b) and (5).
Chemoselective synthesis of pyrazole derivatives via beta-enamino keto esters / M. Manferdini, C. F. Morelli, A. Veronese. - In: HETEROCYCLES. - ISSN 0385-5414. - 53:12(2000), pp. 2775-+.
Chemoselective synthesis of pyrazole derivatives via beta-enamino keto esters
C. F. MorelliSecondo
;
2000
Abstract
beta -Enamino keto ester (2a) reacts with hydroxylamine to give an isoxazole derivative (3). Compound (2a) reacts with hydrazine, alkyl- and arylhydrazines to give pyrazole derivatives (4a-e) as only reaction products. Methylation of compound (4a) afforded the two isomeric pyrazole derivatives (4b) and (5).
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