Fifty-five drug users institutionalized in a community for drug detoxification were vaccinated against hepatitis B virus (HBV) with a recombinant yeast-derived vaccine (Engerix B, Smith Kline Biologicals, Belgium). At 0,1, and 6 months, 20 µg of vaccine was given in the deltoid to these patients, of whom 17 had no serum HBV markers, 15 had only the antibody to core antigen (anti-HBc), and 23 had anti-HBc and antibody to the surface antigen (anti-HBs) values lower than the allegedly "protective" value of 10 mIU/mL. Forty-one healthy controls were vaccinated in parallel. At month 7 (ie, 1 month after the third dose of vaccine), in 76% (13/17) of drug users with no HBV markers, 6% (1/15) of those with isolated anti-HBc, and 69% (16/23) of those with antiHBc and nonprotective anti-HBs, protective anti-HBs titers (≥ 10 mIU/mL) developed, compared with 97% (40/41) of controls. At month 24, these rates fell to 43% for drug users with no HBV marker, 0% for those with anti-HBc, 31% for those with anti-HBc and anti-HBs, and 86% for controls. The drug users who did not respond to vaccination were more likely to be those with evidence of prior HBV infection and anergy to skin tests. This indicates that unresponsiveness to hepatitis B vaccine in drug users may be due to altered immunity

Suboptimal response to hepatitis B vaccine in drug users / M. Rumi, M. Colombo, R. Romeo, A. Boschini, A. Zanetti, A. Gringeri, P.M. Mannucci. - In: ARCHIVES OF INTERNAL MEDICINE. - ISSN 0003-9926. - 151:3(1991 Mar), pp. 574-578.

Suboptimal response to hepatitis B vaccine in drug users

M. Rumi
Primo
;
M. Colombo
Secondo
;
A. Zanetti;A. Gringeri
Penultimo
;
P.M. Mannucci
Ultimo
1991

Abstract

Fifty-five drug users institutionalized in a community for drug detoxification were vaccinated against hepatitis B virus (HBV) with a recombinant yeast-derived vaccine (Engerix B, Smith Kline Biologicals, Belgium). At 0,1, and 6 months, 20 µg of vaccine was given in the deltoid to these patients, of whom 17 had no serum HBV markers, 15 had only the antibody to core antigen (anti-HBc), and 23 had anti-HBc and antibody to the surface antigen (anti-HBs) values lower than the allegedly "protective" value of 10 mIU/mL. Forty-one healthy controls were vaccinated in parallel. At month 7 (ie, 1 month after the third dose of vaccine), in 76% (13/17) of drug users with no HBV markers, 6% (1/15) of those with isolated anti-HBc, and 69% (16/23) of those with antiHBc and nonprotective anti-HBs, protective anti-HBs titers (≥ 10 mIU/mL) developed, compared with 97% (40/41) of controls. At month 24, these rates fell to 43% for drug users with no HBV marker, 0% for those with anti-HBc, 31% for those with anti-HBc and anti-HBs, and 86% for controls. The drug users who did not respond to vaccination were more likely to be those with evidence of prior HBV infection and anergy to skin tests. This indicates that unresponsiveness to hepatitis B vaccine in drug users may be due to altered immunity
Response ; hepatitis B ; vaccine ; drug users
Settore MED/09 - Medicina Interna
Settore MED/42 - Igiene Generale e Applicata
mar-1991
http://archinte.ama-assn.org/cgi/content/abstract/151/3/574
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/156850
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 38
  • ???jsp.display-item.citation.isi??? ND
social impact