The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides / B. La Ferla, L. Lay, M. Guerrini, L. Poletti, L. Panza, G. Russo. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:32(1999), pp. 9867-9880.
Synthesis of disaccharidic sub-units of a new series of heparin related oligosaccharides
L. LaySecondo
;L. Poletti;
1999
Abstract
The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
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