Several findings point out that melanoma culture supernatants release soluble factors which modulate mononuclear cell chemotactic responsiveness. In this regard, either an enhancement or an impairment of chemotactic capacity has been found. Here, we provide evidence that supernatant recovered from human melanoma cell metastasis culture is able to trigger monocyte and polymorphonuclear cell chemotaxis. This activity is not affected by the presence of anti-IL-1 antibody during the assay. Further studies are in progress to isolate and characterize soluble factors involved in this activity.
Human melanoma metastasis culture supernatant contains chemotactic factors for phagocytes / M. T. Ventura, A. Cerri, E. Jirillo, S. Antonaci, L. Bonomo. - In: JOURNAL OF CLINICAL LABORATORY ANALYSIS. - ISSN 0887-8013. - 5:1(1990), pp. 21-24.
Human melanoma metastasis culture supernatant contains chemotactic factors for phagocytes
A. CerriSecondo
;
1990
Abstract
Several findings point out that melanoma culture supernatants release soluble factors which modulate mononuclear cell chemotactic responsiveness. In this regard, either an enhancement or an impairment of chemotactic capacity has been found. Here, we provide evidence that supernatant recovered from human melanoma cell metastasis culture is able to trigger monocyte and polymorphonuclear cell chemotaxis. This activity is not affected by the presence of anti-IL-1 antibody during the assay. Further studies are in progress to isolate and characterize soluble factors involved in this activity.Pubblicazioni consigliate
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