The asymmetric epoxidation of vitamin K3 and analogues in aqueous alkaline buffer solution or in DMF/solid Na2CO3, in the presence of α- and β-cyclodextrin has been investigated. The enantiomeric excesses in the products were up to 48%. The various factors that control the enantioselectivity of the process have been examined. Different mechanisms are involved in aqueous medium and dipolar aprotic solvent.
Biomimetic asymmetric synthesis. Enantioselective Weitz-Scheffer epoxidation of vitamin K3 and analogues in the presence of cyclodextrins / A. Manfredi, R. Annunziata, N. Gaggero, L. Casella, S. Colonna. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 55:23(1990 Nov), pp. 5862-5866.
Biomimetic asymmetric synthesis. Enantioselective Weitz-Scheffer epoxidation of vitamin K3 and analogues in the presence of cyclodextrins
A. Manfredi;R. Annunziata;N. Gaggero;S. Colonna
1990
Abstract
The asymmetric epoxidation of vitamin K3 and analogues in aqueous alkaline buffer solution or in DMF/solid Na2CO3, in the presence of α- and β-cyclodextrin has been investigated. The enantiomeric excesses in the products were up to 48%. The various factors that control the enantioselectivity of the process have been examined. Different mechanisms are involved in aqueous medium and dipolar aprotic solvent.File | Dimensione | Formato | |
---|---|---|---|
jo00310a018.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
630.51 kB
Formato
Adobe PDF
|
630.51 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.