The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.
Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR / L. Corrado, P. Colapietro, L. Larizza, P. Riva. - In: MOLECULAR AND CELLULAR PROBES. - ISSN 0890-8508. - 13:3(1999 Jun), pp. 199-202. [10.1006/mcpr.1999.0237]
Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR
L. CorradoPrimo
;P. ColapietroSecondo
;L. LarizzaPenultimo
;P. RivaUltimo
1999
Abstract
The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.