A DA-Dapi and AgNOR-negative extranumerary chromosome was identified prenatally in a male fetus and also found in his normal father. Fluorescence in situ hybridization using repetitive DNA probes showed that the minute marker was positive at both ends for beta-satellite sequences, while its centromere was recognized by a 22 alphoid probe. It is concluded that the non-mosaic familial marker represents a 22p isochromosome.
Prenatal diagnosis of an extranumerary i(22p) with normal phenotype / L. Doneda, L. Dalprà, M. G. Tibiletti, L. Larizza. - In: ANNALES DE GENETIQUE. - ISSN 0003-3995. - 36:3(1993), pp. 154-158.
Prenatal diagnosis of an extranumerary i(22p) with normal phenotype
L. DonedaPrimo
;L. LarizzaUltimo
1993
Abstract
A DA-Dapi and AgNOR-negative extranumerary chromosome was identified prenatally in a male fetus and also found in his normal father. Fluorescence in situ hybridization using repetitive DNA probes showed that the minute marker was positive at both ends for beta-satellite sequences, while its centromere was recognized by a 22 alphoid probe. It is concluded that the non-mosaic familial marker represents a 22p isochromosome.
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