The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.
Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy / A.R. Zanetti, E. Tanzi, L. Romano', P. Vigano', A. Cargnel, S. Hojvat, A.J. Zuckerman. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 32:4(1990), pp. 219-224. [10.1002/jmv.1890320405]
Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy.
A.R. ZanettiPrimo
;E. TanziSecondo
;L. Romano';
1990
Abstract
The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.Pubblicazioni consigliate
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