2-Amino-1,5-dihydro-1-[methyl-H-2(3)] 4H-imidazol-4-one ([methyl-H-2(3)] creatinine) was obtained by acidification and heating (120-degrees-C, 120 min) of the [methyl -H-2(3)] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-H-2(3)) L-methionine ([methyl-H-2(3)] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7 %.
ENZYMATIC-SYNTHESIS OF [METHYL-(H-2)3] CREATININE / C. ARCELLONI, R. PARONI, P.A.BONINI, F. MAGNI, M.G. KIENLE. - In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. - ISSN 0362-4803. - 31:7(1992 Jul), pp. 505-517.
ENZYMATIC-SYNTHESIS OF [METHYL-(H-2)3] CREATININE
R. PARONISecondo
;
1992
Abstract
2-Amino-1,5-dihydro-1-[methyl-H-2(3)] 4H-imidazol-4-one ([methyl-H-2(3)] creatinine) was obtained by acidification and heating (120-degrees-C, 120 min) of the [methyl -H-2(3)] N-amidinosarcosine (creatine) synthesised by methylation of guanidoacetate (GA) with S-adenosyl-[methyl-H-2(3)) L-methionine ([methyl-H-2(3)] AdoMet) in the presence of rat liver guanidoacetate methyltransferase (GAA-MT). Isotopic enrichment was 94.7 %.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.