The synthesis and radioligand binding assays of a group of muscarinic ligands related to oxotremorine are reported. The new compounds displayed binding affinities comparable to those of the parent molecule with the exception of the trimethylammonium salt 6, which behaved as a fill muscarinic agonist and showed a pronounced selectivity for M-2 versus M-1 muscarinic receptor subtypes. (C) 1997 Elsevier Science Ltd.
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine / P. Conti, C. Dallanoce, M. De Amici, C. De Micheli, B. Ebert. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 7:8(1997), pp. 1033-1036.
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine
P. ContiPrimo
;C. DallanoceSecondo
;M. De Amici;C. De MicheliPenultimo
;
1997
Abstract
The synthesis and radioligand binding assays of a group of muscarinic ligands related to oxotremorine are reported. The new compounds displayed binding affinities comparable to those of the parent molecule with the exception of the trimethylammonium salt 6, which behaved as a fill muscarinic agonist and showed a pronounced selectivity for M-2 versus M-1 muscarinic receptor subtypes. (C) 1997 Elsevier Science Ltd.
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