In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the "immunoblot" technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.
Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: detection by ELISA / E. Nobile-Orazio, T. Vietorisz, M.J. Messito, W.H. Sherman, N. Latov. - In: NEUROLOGY. - ISSN 0028-3878. - 33:7(1983 Jul), pp. 939-42-942.
Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: detection by ELISA
E. Nobile-OrazioPrimo
;
1983
Abstract
In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the "immunoblot" technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.Pubblicazioni consigliate
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