Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein electrophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

Neuropathy and anti-MAG antibodies without detectable serum M-protein / E. Nobile-Orazio, N. Latov, A. P. Hays, M. Takatsu, G. M. Abrams, W. H. Sherman, J. R. Miller, M. J. Messito, T. Saito, A. Tahmoush. - In: NEUROLOGY. - ISSN 0028-3878. - 34:2(1984 Feb), pp. 218-21-221.

Neuropathy and anti-MAG antibodies without detectable serum M-protein

E. Nobile-Orazio
Primo
;
1984

Abstract

Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein electrophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.
Blood Proteins; Myelin-Associated Glycoprotein; Myelin Proteins; Peripheral Nervous System Diseases; Humans; Enzyme-Linked Immunosorbent Assay; Aged; Male; Immunoglobulin M; Antibodies, Anti-Idiotypic
Settore MED/26 - Neurologia
feb-1984
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/183217
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