The metabolism of Bezafibrate, a new lipid lowering drug, was studied in vitro using rat liver subcellular fractions as enzymes source. The drug is metabolized in rat liver microsomes through C-oxidation by a cytochrome P-450 mediated process to hydroxy-Bezafibrate. The extent of hydroxy-Bezafibrate formation is limited, because of the type of Bezafibrate interaction with, and its binding parameters to rat liver cytochrome P-450. The mechanism of hydroxy-Bezafibrate formation by rat liver microsomal cytochrome P-450 is discussed.
"In vitro" metabolism of bezafibrate by rat liver / R. Maffei Facino, M. Carini, R. Bertuletti, O. Tofanetti. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 13:2(1981), pp. 121-132.
"In vitro" metabolism of bezafibrate by rat liver
R. Maffei FacinoPrimo
;M. CariniSecondo
;
1981
Abstract
The metabolism of Bezafibrate, a new lipid lowering drug, was studied in vitro using rat liver subcellular fractions as enzymes source. The drug is metabolized in rat liver microsomes through C-oxidation by a cytochrome P-450 mediated process to hydroxy-Bezafibrate. The extent of hydroxy-Bezafibrate formation is limited, because of the type of Bezafibrate interaction with, and its binding parameters to rat liver cytochrome P-450. The mechanism of hydroxy-Bezafibrate formation by rat liver microsomal cytochrome P-450 is discussed.
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